Ms. Jamesoni was a female Jameson's mamba who had escaped from a venomous reptile-rearing facility somewhere in the outskirts of Miami. Upon her escape, she explored through a hedge but had been spooked by an oblivious jogger, whom the snake had bit in fear. She then somehow ended up in a McDonald's somewhere in the ghetto, and caused hysteria by some people who happened to be there. A young girl, her mother and a boy were bitten and probably died in the hospital. Animal control attempted to capture the serpent but she dipped out quite fast.

She slithered through the treetops, snacking on a young iguana and biting a scissor-tailed kite in fear. However, she had to cross a road, and that was a huge risk. She did anyway, only to be accidentally crushed and flattened by a motorcycle gang.